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Advice for Altitude Sickness

Altitude sickness, also known as acute mountain sickness (AMS), is a condition that can occur when a person ascends to high altitudes—typically above 2,500 meters (8,200 feet)—too quickly, without giving the body enough time to adjust to lower oxygen levels. It can affect anyone, regardless of age, fitness level, or experience at altitude.

Mild symptoms often appear within hours of arrival and may include headache, nausea, fatigue, dizziness, loss of appetite, and difficulty sleeping. These symptoms are usually manageable with rest, hydration, and slower ascent. However, in some cases, altitude sickness can progress to more serious forms such as High-Altitude Cerebral Edema (HACE), which affects the brain and causes confusion, coordination problems, or unconsciousness, and High-Altitude Pulmonary Edema (HAPE), which causes fluid buildup in the lungs, leading to breathlessness, chest tightness, and a wet cough. Both are medical emergencies requiring immediate descent and treatment.

Pharmacists can support travelers by recommending gradual ascent schedules, offering advice on hydration and rest, and providing preventive medications like acetazolamide (Diamox), which helps the body acclimatize more effectively. If you're planning a trip to a high-altitude destination, speak with your pharmacist about how to prepare and what to carry for safe travel at elevation.

Altitude sickness can cause a range of symptoms, which typically begin within 6 to 24 hours after ascending to high altitudes—usually above 2,500 meters (8,200 feet). Symptoms can be mild at first but may become more serious if ignored or if the person continues to ascend without proper acclimatization.

The most common early symptom is a headache, which may feel dull or throbbing and is often not relieved by usual pain medication. Many people also experience nausea, vomiting, or a general loss of appetite. Dizziness or lightheadedness is common, particularly when standing up or moving around. Fatigue is often present and may not improve with rest. People may notice shortness of breath during physical activity, even if the activity is not strenuous.

Sleep disturbances are also frequent and may include difficulty falling asleep, frequent waking, or vivid dreams. Swelling of the hands, face, or feet (known as peripheral edema) can occur due to fluid retention. Other signs include a rapid heartbeat, general weakness, and irritability or feeling mentally "foggy."

In more severe cases, altitude sickness can progress to high-altitude cerebral edema (HACE), a potentially fatal condition involving swelling of the brain. Symptoms of HACE include severe, persistent headache, loss of coordination or balance (ataxia), confusion, slurred speech, drowsiness, visual disturbances, and in some cases, hallucinations or unconsciousness. HACE requires immediate descent and emergency medical care.

Another life-threatening form is high-altitude pulmonary edema (HAPE), which involves fluid buildup in the lungs. Symptoms of HAPE include shortness of breath even while resting, a dry or productive cough that may produce pink, frothy sputum, chest tightness or congestion, and extreme fatigue. Breathing may become noisy or labored, and lips or fingertips may appear blue or gray due to lack of oxygen. A person with HAPE may be unable to walk or speak clearly and can rapidly deteriorate without treatment.

If any of the severe symptoms of HACE or HAPE occur—such as confusion, difficulty walking, severe breathlessness at rest, or loss of consciousness—it is a medical emergency. Immediate descent and oxygen therapy are essential for survival.


Altitude sickness occurs when the body cannot adjust quickly enough to the **lower oxygen levels and reduced air pressure** found at **high altitudes**, usually above **2,500 meters (8,200 feet)**. As you ascend, the air becomes thinner, meaning each breath contains fewer oxygen molecules. This results in less oxygen reaching the brain, muscles, and other organs.

The primary cause of altitude sickness is **ascending too quickly** without allowing the body time to **acclimatize**. Rapid ascent doesn't give your body enough time to adapt to the changing environment, leading to symptoms such as headache, nausea, and fatigue.

Other contributing factors include **overexertion shortly after arrival**, **dehydration**, **alcohol consumption**, and **underlying medical conditions** such as lung or heart disease. Sleeping at a high altitude, especially on the first night, also increases the risk of symptoms. While physical fitness can help with endurance, it does **not protect against altitude sickness**—even healthy, athletic individuals can be affected.



Acetazolamide (brand name Diamox) is commonly used off-label for the prevention and treatment of altitude sickness in the UK, although it is not officially licensed for this purpose. It is prescribed by healthcare professionals based on clinical judgment.

Dosage and Use:

Prevention (Prophylaxis):
The usual dose is 125 mg taken twice daily. It should be started one to two days before ascending to high altitude and continued for at least 48 hours after arrival or until acclimatization occurs.

Treatment of Mild Acute Mountain Sickness (AMS):
If symptoms develop, the dose may be increased to 250 mg twice daily until symptoms improve, along with rest and hydration.

Sleeping Difficulties at Altitude:
A single dose of 125 mg about two hours before sleep may be used to help with breathing problems related to altitude. This can be increased to twice daily if needed.

Severe AMS or High-Altitude Cerebral Edema (HACE):
Acetazolamide is used alongside urgent descent at a dose of 250 mg twice daily.

How It Works:

Acetazolamide inhibits the enzyme carbonic anhydrase, which causes the kidneys to excrete bicarbonate. This results in mild metabolic acidosis, stimulating the body to breathe more deeply and frequently, improving oxygen uptake especially during sleep.
**Gradual Ascent and Acclimatization**
The most effective way to prevent altitude sickness is to ascend slowly, giving the body time to adapt to the reduced oxygen levels. It is generally recommended to limit the ascent to 300 to 500 meters (1,000 to 1,600 feet) per day once above 2,500 meters (8,200 feet), and to include rest days every two to three days.

**Rest and Hydration**
Rest is essential to help the body cope with altitude stress. Staying well-hydrated supports acclimatization and can help reduce symptoms. Alcohol and sedatives should be avoided because they can worsen breathing problems during sleep.

**Supplemental Oxygen**
Providing additional oxygen increases the amount of oxygen in the bloodstream and can quickly relieve symptoms such as headache, nausea, and shortness of breath. Portable oxygen tanks are commonly used in high-altitude environments or emergency situations.

**Dexamethasone**
Dexamethasone is a corticosteroid used to treat severe forms of altitude sickness, particularly high-altitude cerebral edema (HACE). It reduces inflammation and brain swelling and is used in emergencies alongside descent and oxygen therapy. It is not used for mild symptoms.

**Nifedipine**
Nifedipine, a calcium channel blocker, is prescribed for high-altitude pulmonary edema (HAPE). It lowers pulmonary artery pressure, which helps reduce fluid accumulation in the lungs and improves breathing. This medication is used when oxygen therapy or descent is not immediately possible.

**Phosphodiesterase Inhibitors (Sildenafil, Tadalafil)**
These medications help reduce pulmonary hypertension and may be used as adjunct treatment for HAPE. They are less commonly prescribed and typically reserved for specific cases or when other treatments are unavailable.

Frequently Asked Questions