Alfuzosin Hydrochloride Tablets

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Alfuzosin Hydrochloride Tablets

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Alfuzosin is a medication used to treat benign prostatic hyperplasia (BPH), a condition where the prostate enlarges and causes urinary problems. It works by relaxing the smooth muscles in the prostate and the bladder neck, which helps improve urine flow and reduces symptoms like a weak stream, difficulty starting urination, and night time urination. Alfuzosin is usually taken once daily in extended-release tablets, making it convenient for patients. It generally has fewer cardiovascular side effects compared to other alpha-blockers and does not significantly lower blood pressure in most people. Common side effects include dizziness, headache, and fatigue, while serious side effects are rare. It is important to monitor blood pressure when starting or adjusting the dose, especially in patients taking other blood pressure medications. Overall, alfuzosin is an effective and well-tolerated option for managing BPH symptoms, especially in patients with coexisting hypertension.

Alfuzosin is usually prescribed as a 10 mg extended-release tablet taken once daily after a meal. In certain cases, a lower dose such as 2.5 mg may be prescribed, often as an initial dose or for patients who are more sensitive to side effects. If combining both doses, your healthcare provider may recommend starting with 2.5 mg and gradually increasing to 10 mg based on your response and tolerance. Always follow your doctor’s specific instructions regarding dosing, and do not adjust the dose yourself without medical advice.

Alfuzosin can cause a range of side effects, although not everyone experiences them. Common side effects include dizziness, especially when standing up quickly (orthostatic hypotension), headache, fatigue, and weakness. Some patients may experience nausea or gastrointestinal discomfort. Dizziness and lightheadedness are more likely when starting therapy or increasing the dose, so it's important to rise slowly from sitting or lying positions.

Less common but more serious side effects include severe dizziness, fainting, or allergic reactions such as rash, itching, swelling, or difficulty breathing. In rare cases, alfuzosin can cause vision changes, chest pain, or wakeful episodes related to blood pressure fluctuations.

Because alfuzosin relaxes blood vessels, it can sometimes cause a significant decrease in blood pressure, leading to symptoms like dizziness or fainting, particularly in patients taking other antihypertensive medications. Monitoring for side effects and reporting any unusual symptoms to your healthcare provider is advised for safe use.
Caution and warnings for alfuzosin include the risk of hypotension (low blood pressure), especially when starting treatment or increasing the dose, which can cause dizziness, fainting, or falls. It should be used with caution in patients taking other blood pressure-lowering medications, as combined effects may increase the risk of excessive blood pressure reduction.

Alfuzosin should be used cautiously in patients with liver impairment, as they may process the medication less efficiently, leading to higher blood levels and increased side effects. It is also contraindicated in patients with a history of allergic reactions to the drug.

Patients should be warned to rise slowly from a seated or lying position to reduce the risk of orthostatic hypotension. Additionally, prior to surgery or medical procedures, patients should inform their healthcare provider about alfuzosin use, as it may affect blood pressure management.

Patients with a history of angle-closure glaucoma should discuss this with their doctor, as alfuzosin can potentially affect intraocular pressure. Overall, careful monitoring and medical supervision are essential during treatment with alfuzosin.

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